Sinopol®’s unique 3-in-1 formulation is a health supplement that helps women with Polycystic Ovarian Syndrome (PCOS) restore balance to their hormones and metabolic indicators such as insulin, glucose and cholesterol, and to help regulate menstrual cycles and therefore improve reproductive health. 1-5 Sinopol® contains the powerful antioxidant Alpha-lipoic Acid, Myo-Inositol and Folic Acid. 5 Myo- Inositol may help to reduce insulin resistance in patients with PCOS, Alpha-Lipoic Acid is an antioxidant which reduces oxidative stress and may help to promote healthy glucose metabolism and Folic Acid helps the body to metabolise proteins, helps to form red blood cells and to reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy.
1. Rago R, Marcucci I, Leto G, et al. Effect of myo-inositol and alpha-lipoic acid on oocyte quality in polycystic ovary syndrome non-obese women undergoing in vitro fertilization: a pilot study. J Biol Regulators Homeostatic Agents 2015;29(4):1-11. 2. Genazzani AD, Shefer K, Della Casa D, et al. Modulatory effects of alpha‑lipoic acid (ALA) administration on insulin sensitivity in obese PCOS patients. J Endocrinol Invest 2018;41:583–590. 3. Carbonelli MG, Di Renzo L, Bigioni M, et al. α-Lipoic Acid Supplementation: A Tool for Obesity Therapy? Curr Pharmaceut Design 2010;16:840-846. 4. De Cicco S, Immediata V, Romualdi D, et al. Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin independent action. Gynecol Endocrinol 2017;33(9):698–701. 5. Sinopol® package insert, February 2019.
Proprietary name (and dosage form): SINOPOL® granules. Composition: Each sachet contains: Myo- inositol 1 000 mg, Alpha Lipoic Acid 400 mg and Folic Acid 200 μg. Complementary Medicine: Health Supplement. D34.12 Multiple Substance formulation. This unregistered medicine has not been evaluated by SAHPRA for its quality, safety or intended use. Studies as part of the references were not conducted on Sinopol®. Name and business address of applicant: iNova Pharmaceuticals (Pty) Limited. Co. Reg. No. 1952/001640/07, 15e Riley Road, Bedfordview. Tel. No. 011 087 0000. www.inovapharma.co.za. For more information, speak to your healthcare professional. Further information is available on request from iNova Pharmaceuticals.